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Sigl, C.* ; Willner, E.M.* ; Engelen, W.* ; Kretzmann, J.A.* ; Sachenbacher, K.* ; Liedl, A.* ; Kolbe, F. ; Wilsch, F. ; Aghvami, S.A.* ; Protzer, U. ; Hagan, M.F.* ; Fraden, S.* ; Dietz, H.*

Programmable icosahedral shell system for virus trapping.

Nat. Mater. 20, 1281–1289 (2021)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Broad-spectrum antiviral platforms that can decrease or inhibit viral infection would alleviate many threats to global public health. Nonetheless, effective technologies of this kind are still not available. Here, we describe a programmable icosahedral canvas for the self-assembly of icosahedral shells that have viral trapping and antiviral properties. Programmable triangular building blocks constructed from DNA assemble with high yield into various shell objects with user-defined geometries and apertures. We have created shells with molecular masses ranging from 43 to 925 MDa (8 to 180 subunits) and with internal cavity diameters of up to 280 nm. The shell interior can be functionalized with virus-specific moieties in a modular fashion. We demonstrate this virus-trapping concept by engulfing hepatitis B virus core particles and adeno-associated viruses. We demonstrate the inhibition of hepatitis B virus core interactions with surfaces in vitro and the neutralization of infectious adeno-associated viruses exposed to human cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Accurate Design; Dna; Shapes
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1476-1122
e-ISSN 1476-1122
Journal Nature materials
Quellenangaben Volume: 20, Issue: , Pages: 1281–1289 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Basingstoke
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
Grants Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
Deutsche Forschungsgemeinschaft (German Research Foundation)
National Science Foundation (NSF)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
DOI 10.1038/s41563-021-01020-4
WOS ID WOS:000661400000002
Scopus ID 85107888968
PubMed ID 34127822
Erfassungsdatum 2021-06-23
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