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Correa-Gallegos, D. ; Rinkevich, Y.

Cutting into wound repair.

FEBS J. 289, 5034-5048 (2021)
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The skin is home to an assortment of fibroblastic lineages that shape the wound repair response towards scars or regeneration. In this review, we discuss the distinct embryonic origins, anatomic locations, and functions of fibroblastic lineages, and how these distinct lineages of fibroblasts dictate the skin's wound response across injury depths, anatomic locations, and embryonic development to promote either scarring or regeneration. We highlight the supportive role of the fascia in dictating scarring outcomes, we then discuss recent findings that indicate fascia mobilization by its resident fibroblasts supersede the classical de novo deposition program of wound matrix formation. These recent findings reconfigure our traditional view of wound repair and presents exciting new therapeutic avenues to treat scarring and fibrosis across a range of medical settings.
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Publication type Article: Journal article
Document type Review
Keywords Tissue Regeneration ; Fibroblast Heterogeneity ; Matrix Mobilization ; Skin Scarring ; Superficial Fascia; Dermal Fibroblasts; Reticular Fibroblasts; Superficial Fascia; Human Papillary; Skin Thickness; Scar Formation; Neural-crest; Oral Mucosal; Growth; Regeneration
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1742-464X
e-ISSN 1742-4658
Journal FEBS Journal, The
Quellenangaben Volume: 289, Issue: 17, Pages: 5034-5048 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
G-554000-001
Grants European Research Council
Else-Kroner-Fresenius-Stiftung
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award
DOI 10.1111/febs.16078
WOS ID WOS:000664716100001
Scopus ID 85108381470
PubMed ID 34137168
Erfassungsdatum 2021-07-13
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