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Quantification of differential response of tumour and normal cells to microbeam radiation in the absence of flash effects.
Cancers 13:3238 (2021)
Microbeam radiotherapy (MRT) is a preclinical method of delivering spatially-fractionated radiotherapy aiming to improve the therapeutic window between normal tissue complication and tumour control. Previously, MRT was limited to ultra-high dose rate synchrotron facilities. The aim of this study was to investigate in vitro effects of MRT on tumour and normal cells at conventional dose rates produced by a bench-top X-ray source. Two normal and two tumour cell lines were exposed to homogeneous broad beam (BB) radiation, MRT, or were separately irradiated with peak or valley doses before being mixed. Clonogenic survival was assessed and compared to BB-estimated surviving fractions calculated by the linear-quadratic (LQ)-model. All cell lines showed similar BB sensitivity. BB LQ-model predictions exceeded the survival of cell lines following MRT or mixed beam irradiation. This effect was stronger in tumour compared to normal cell lines. Dose mixing experiments could reproduce MRT survival. We observed a differential response of tumour and normal cells to spatially fractionated irradiations in vitro, indicating increased tumour cell sensitivity. Importantly, this was observed at dose rates precluding the presence of FLASH effects. The LQ-model did not predict cell survival when the cell population received split irradiation doses, indicating that factors other than local dose influenced survival after irradiation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Clonogenic Survival ; Compact Source ; In Vitro ; Integral Dose ; Lq Model ; Microbeam ; Spatial Fractionation; X-ray-beams; Synchrotron; Bystander; Therapy; Irradiation; Brain; Tolerance; Carcinoma; Pathways; Damage
ISSN (print) / ISBN
2072-6694
Journal
Cancers
Quellenangaben
Volume: 13,
Issue: 13,
Article Number: 3238
Publisher
MDPI
Publishing Place
St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Medicine (IRM)
Grants
Cancer Research UK