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Open Access Green as soon as Postprint is submitted to ZB.
Sensitivity of the quorum sensing system is achieved by low pass filtering.
Biosystems 92, 76-81 (2008)
Autoinducer sensing, also known as quorum sensing, is the communication of bacteria by autoinducer (small signaling molecules). Cells respond on extremely low concentrations of autoinducer: only one or two molecules per cell are sufficient. At this signal level a high degree of noise is inherent. We ask for the mechanism that is able to overcome the stochasticity of the signal. By means of a model and parameter fitting we show that the sensing module acts as a low pass filter, representing the biochemical equivalent of a moving average. It is shown that the system works most sensitive in the range of 0-50 nM autoinducer. Moreover, the time scale of the reaction depends on the signal strength in a crucial manner. Nonlinear feedback is able to further enhance the sensitivity. The biological implications of the low pass filter property are discussed.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Quorum sensing; Efficiency sensing; Cell–cell communication; Noise reduction
ISSN (print) / ISBN
0303-2647
e-ISSN
1872-8324
Quellenangaben
Volume: 92,
Issue: 1,
Pages: 76-81
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biomathematics and Biometry (IBB)