Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
Research data
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55-87 years.
Sci. Rep. 11, 13852:13852 (2021)
The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55-87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = - 0.042 (verbal fluency) and - 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI - 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55-65 years, 66-75 years, > 75 years). In the 66-75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Functional Variant; Plasma Klotho; Gene; Association; Mortality; Risk
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Journal
Scientific Reports
Quellenangaben
Volume: 11,
Issue: 1,
Pages: 13852
Article Number: 13852
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)
Grants
Heinz Nixdorf Foundation
German Research Council (DFG)
German Ministry of Education and Science [BMBF]
Ministry of Innovation, Science, Research and Technology, North Rhine-Westphalia (MIWFT-NRW)
Janssen
Merck KG
Philips
ResMed Foundation
Roche Diagnostics
Sarstedt AGCo
Siemens HealthCare Diagnostics
Volkswagen Foundation
Imatron/GE-Imatron
Celgene GmbH Munchen
Dr. Werner-Jackstadt Stiftung
Else Kroner-Fresenius-Stiftung
German Social Accident Insurance [DGUV]
Competence Network for HIV/AIDS
IFORES of the University Duisburg-Essen
European Union
German Competence Network Heart Failure
Kulturstiftung Essen
Protein Research Unit within Europe (PURE)
Projekt DEAL
German Research Council (DFG)
German Ministry of Education and Science [BMBF]
Ministry of Innovation, Science, Research and Technology, North Rhine-Westphalia (MIWFT-NRW)
Janssen
Merck KG
Philips
ResMed Foundation
Roche Diagnostics
Sarstedt AGCo
Siemens HealthCare Diagnostics
Volkswagen Foundation
Imatron/GE-Imatron
Celgene GmbH Munchen
Dr. Werner-Jackstadt Stiftung
Else Kroner-Fresenius-Stiftung
German Social Accident Insurance [DGUV]
Competence Network for HIV/AIDS
IFORES of the University Duisburg-Essen
European Union
German Competence Network Heart Failure
Kulturstiftung Essen
Protein Research Unit within Europe (PURE)
Projekt DEAL