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Lu, K.* ; Lai, K.P.* ; Stöger, T. ; Ji, S.* ; Lin, Z.* ; Lin, X.* ; Chan, T.F.* ; Fang, J.K.* ; Lo, M.* ; Gao, L.* ; Qiu, C.* ; Chen, S.* ; Chen, G.* ; Li, L.* ; Wang, L.*

Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology.

J. Hazard. Mater. 416:126069 (2021)
Postprint DOI PMC
Open Access Green
Concerns that airborne microplastics (MP) may be detrimental to human health are rising. However, research on the effects of MP on the respiratory system are limited. We tested the effect of MP exposure on both normal and asthmatic pulmonary physiology in mice. We show that MP exposure caused pulmonary inflammatory cell infiltration, bronchoalveolar macrophage aggregation, increased TNF-alpha level in bronchoalveolar lavage fluid (BALF), and increased plasma IgG1 production in normal mice. MP exposure also affected asthma symptoms by increasing mucus production and inflammatory cell infiltration with notable macrophage aggregation. Further, we found co-labeling of macrophage markers with MP incorporating fluorescence, which indicates phagocytosis of the MP by macrophages. A comparative transcriptomic analysis showed that MP exposure altered clusters of genes related to immune response, cellular stress response, and programmed cell death. A bioinformatics analysis further uncovered the molecular mechanism whereby MP stimulated production of tumor necrosis factor and immunoglobulins to activate a group of transmembrane B-cell antigens, leading to the modulation of cellular stress and programmed cell death in the asthma model. In summary, we show that MP exposure had detrimental effects on the respiratory system in both healthy and asthmatic mice, which calls for urgent discourse and action to mitigate environmental microplastic pollutants.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Microplastic ; Asthma ; Respiratory System ; Health Risk ; Transcriptome; Necrosis-factor-alpha; Sex-hormones; Inflammation; Mercury; Lung; Bioaccumulation; Sensitization; Particles; Release; Indoor
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0304-3894
e-ISSN 1873-3336
Journal Journal of Hazardous Materials
Quellenangaben Volume: 416, Issue: , Pages: , Article Number: 126069 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-001
Grants Key-Area Research and Development Program of Guangdong Province
Macao SAR
Hong Kong SAR
National Natural Science Foundation of China (NSFC)
Clinical research of Health and Family Planning Commission of Shenzhen Municipality
Guangdong International Cooperation Grant
Shenzhen Science Technology and Innovative Commission (SZSTI)
Taiwan Province Talent Young Scientist Program of Guangxi
DOI 10.1016/j.jhazmat.2021.126069
WOS ID WOS:000664878600001
Scopus ID 85110280611
PubMed ID 34492895
Erfassungsdatum 2021-07-16
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