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Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors.
Proc. SPIE 11642:116422L (2021)
Ultrasound (US) and optoacoustic (OA) imaging provide complementary information for quantitative analysis of the tumor microenvironment. Herein, we demonstrate the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS) for characterizing breast cancer in tumor-bearing mice. For this, 4 different mice featuring orthotopic tumor of different sizes were scanned with a full-ring ultrasound transducer array to simultaneously render pulse-echo US images, speed of sound (SoS) maps and OA images. The tumor size, vascular density and its elastic parameters were further quantified in the images. Our results pave the way toward clinical translation of the hybrid TROPUS imaging for tumor detection and characterization.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cancer Research ; Optoacoustic Imaging ; Photoacoustics ; Preclinical Imaging Of Tumors ; Speed Of Sound Imaging ; Ultrasound Computed Tomography
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Journal
Proceedings of SPIE
Quellenangaben
Volume: 11642,
Article Number: 116422L
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
Deutsche Forschungsgemeinschaft (DFG German Research Foundation) Germany's Excellence Strategy