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Open Access Green as soon as Postprint is submitted to ZB.
Diversity of T helper and regulatory T cells and their contribution to the pathogenesis of allergic diseases.
In:. Berlin ; Heidelberg: Springer, 2021. 265-296 (Handb. Exp. Pharmacol. ; 268)
T helper (Th) and regulatory T (Treg) cells represent important effectors of adaptive immunity. They mediate communication between the immune system and tissue sites and thereby coordinate effective defense against environmental threats or maintain tolerance, respectively. Since the discovery of two prototypic T helper cells, Th1 and Th2, additional phenotypic and functional distinct subsets have been described ranging from Th17, Th22, Th9, and T follicular helper cells. The same holds true for regulatory T cells that represent a family with functionally distinct subsets characterized by co-expression of the transcription factors T-bet, Gata3, or RORγt. Here, we summarize the current knowledge on differentiation and function of T helper and regulatory T cell subsets and discuss their lineage stability versus plasticity towards other subsets. In addition, we highlight the direct and indirect contribution of each subset to the pathology of allergies and indicate novel therapies for specific targeting the effector functions of T helper and regulatory T cells.
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Publication type
Article: Edited volume or book chapter
Keywords
Allergy ; Plasticity ; Regulatory T Cells (treg) ; T Helper Cells (th Cells)
ISSN (print) / ISBN
0171-2004
Quellenangaben
Volume: 268,
Pages: 265-296
Publisher
Springer
Publishing Place
Berlin ; Heidelberg
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)