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Andörfer, L.* ; Holtfreter, B.* ; Weiss, S.* ; Matthes, R.* ; Pitchika, V.* ; Schmidt, C.O.* ; Samietz, S.* ; Kastenmüller, G. ; Nauck, M.* ; Völker, U.* ; Völzke, H.* ; Csonka, L.N.* ; Suhre, K. ; Pietzner, M.* ; Kocher, T.*

Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting.

BMC Med. 19:161 (2021)

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BACKGROUND: Periodontitis is among the most common chronic diseases worldwide, and it is one of the main reasons for tooth loss. Comprehensive profiling of the metabolite content of the saliva can enable the identification of novel pathways associated with periodontitis and highlight non-invasive markers to facilitate time and cost-effective screening efforts for the presence of periodontitis and the prediction of tooth loss. METHODS: We first investigated cross-sectional associations of 13 oral health variables with saliva levels of 562 metabolites, measured by untargeted mass spectrometry among a sub-sample (n = 938) of the Study of Health in Pomerania (SHIP-2) using linear regression models adjusting for common confounders. We took forward any candidate metabolite associated with at least two oral variables, to test for an association with a 5-year tooth loss over and above baseline oral health status using negative binomial regression models. RESULTS: We identified 84 saliva metabolites that were associated with at least one oral variable cross-sectionally, for a subset of which we observed robust replication in an independent study. Out of 34 metabolites associated with more than two oral variables, baseline saliva levels of nine metabolites were positively associated with a 5-year tooth loss. Across all analyses, the metabolites 2-pyrrolidineacetic acid and butyrylputrescine were the most consistent candidate metabolites, likely reflecting oral dysbiosis. Other candidate metabolites likely reflected tissue destruction and cell proliferation. CONCLUSIONS: Untargeted metabolic profiling of saliva replicated metabolic signatures of periodontal status and revealed novel metabolites associated with periodontitis and future tooth loss.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords 2-pyrrolidineacetic Acid ; Butyrylputrescine ; Cohort Study ; Metabolomics ; Periodontitis ; Progression ; Tooth Loss; Porphyromonas-gingivalis Proteinases; Phenylacetic Acid; Reactive Oxygen; N-acetyltaurine; Severe Periodontitis; Genotype Imputation; Oral-diseases; Health; Metabolomics; Degradation

ISSN (print) / ISBN 1741-7015

e-ISSN 1741-7015

Journal BMC Medicine

Quellenangaben Volume: 19, Issue: 1, Article Number: 161

Publisher BioMed Central

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)

Grants National Science Foundation
German Federal Ministry of Education and Research