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Weusthof, K.* ; Lüttich, P.* ; Regnery, S.* ; König, L.M.* ; Bernhardt, D. ; Witt, O.* ; Unterberg, A.* ; Jungk, C.* ; Farnia, B.* ; Combs, S.E. ; Rieken, S.*

Neurocognitive outcomes in pediatric patients following brain irradiation.

Cancers 13:3538 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Advanced radiation techniques can reduce the severity of neurocognitive sequelae in young brain tumor patients. In the present analysis, we sought to compare neurocognitive outcomes after proton irradiation with patients who underwent photon radiotherapy (RT) and surgery. Neurocogni-tive outcomes were evaluated in 103 pediatric brain tumor patients (proton RT n = 26, photon RT n = 30, surgery n = 47) before and after treatment. Comparison of neurocognitive outcomes following different treatment modalities were analyzed over four years after treatment completion. Longitudinal analyses included 42 months of follow-up after proton RT and 55 months after photon RT and surgery. Neurocognitive assessment included standardized tests examining seven domains. A comparison of neurocognitive outcomes after RT (proton and photon with >90% additional surgery) and surgery showed no significant differences in any neurocognitive domain. Neurocognitive functioning tests after proton RT failed to identify alterations compared to baseline testing. Long-term follow up over four years after photon RT showed a decrease in non-verbal intelligence (−9.6%; p = 0.01) and visuospatial construction (−14.9%; p = 0.02). After surgery, there was a decline in non-verbal intelligence (−10.7%; p = 0.01) and processing speed (14.9%; p = 0.002). Differences in neurocognitive outcomes between RT and surgical cohorts in direct intermodal comparison at long-term follow-up were not identified in our study, suggesting that modern radiation therapy does not affect cognition as much as in the past. There were no alterations in long-term neurocognitive abilities after proton RT, whereas decline of processing speed, non-verbal intelligence, and visuospatial abilities were observed after both photon RT and surgery. Domains dependent on intact white matter structures appear particularly vulnerable to brain tumor treatment irrespective of treatment approach.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Neurocognitive Function ; Neuropsychological Assessment ; Pediatric Brain Tumor ; Photon Irradiation ; Proton Irradiation ; Treatment Modality Com-parison; Conformal Radiation-therapy; Osterrieth Complex Figure; Central-nervous-system; Intelligence Quotient; Proton Therapy; Radiotherapy; Childhood; Children; Tumors; Plasticity
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2072-6694
Journal Cancers
Quellenangaben Volume: 13, Issue: 14, Pages: , Article Number: 3538 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
Grants Dietmar Hopp Stiftung
DOI 10.3390/cancers13143538
WOS ID WOS:000676489400001
Scopus ID 85110115431
PubMed ID 34298751
Erfassungsdatum 2021-08-02
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