Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
as soon as is submitted to ZB.
Bioengineered bacterial vesicles for optoacoustics-guided phototherapy.
Methods Enzymol. 657, 349-364 (2021)
Genetically engineered bacterial outer membrane vesicles (OMVs) offer promising applications for gene therapy, immunotherapy, and vaccine delivery. Importantly, OMVs are biocompatible, biodegradable, and easy to engineer and produce on a large scale. In this chapter, we discuss the development and application of bioengineered OMVs for optoacoustics-guided phototherapy applications (theranostics). We provide detailed protocols for OMVs preparation, characterization, and in vitro and in vivo validation. The engineered OMVs carry the biopolymer melanin, which generates a strong optoacoustic (OA) signal and intense heat upon absorption of near-infrared (NIR) light, enabling optoacoustics-guided cancer diagnosis and photothermal therapy in vivo.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Bacterial Outer Membrane Vesicles ; Cancer ; Melanin ; Optoacoustics ; Phototherapy ; Theranostics; Outer-membrane Vesicles
ISSN (print) / ISBN
0076-6879
e-ISSN
0076-6879
Journal
Methods in Enzymology
Quellenangaben
Volume: 657,
Pages: 349-364
Publisher
Elsevier
Publishing Place
525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
DFG
Deutsche Forschungsgemeinschaft (DFG), Germany
European Research Council (ERC) under the European Union
Deutsche Forschungsgemeinschaft (DFG), Germany
European Research Council (ERC) under the European Union