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Fuse your mitochondria, lose appetite: An anorexic, anti-obesity sphingolipid.
EMBO Mol. Med.:e14618 (2021)
Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017). Ceramides are formed by recycling or de novo synthesis from sphingosine and a fatty acid side chain moiety. The side chain length determines lipotoxicity of ceramides, as those composed of C16:0 or C18:0 side chains are toxic whereas those with C24:0 or C24:1 are not (Meikle and Summers 2017). Counteracting the deleterious effects of high-fat diets (HFDs) rich in saturated fat either by inhibiting synthesis or by promoting degradation of ceramides mitigates insulin resistance and ectopic lipid accumulation (Meikle and Summers 2017). However, drugs that safely and selectively target ceramide metabolism have failed to translate into metabolic benefit in human trials so far.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Er Stress; Mff
ISSN (print) / ISBN
1757-4676
e-ISSN
1757-4684
Journal
EMBO Molecular Medicine
Quellenangaben
Article Number: e14618
Publisher
Wiley
Publishing Place
Chichester
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
DFG