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Demir, S. ; Nawroth, P.P. ; Herzig, S. ; Ekim Üstünel, B.

Emerging targets in type 2 diabetes and diabetic complications.

Adv. Sci., e2100275 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications.
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Publication type Article: Journal article
Document type Review
Keywords Insulin Resistance ; Metabolism ; Signaling Pathways ; Type 2 Diabetes, Diabetic Complications; Magnetic-resonance Neurography; Improves Insulin Sensitivity; Intensive Glucose Control; Beta-cell Dysfunction; Kidney-disease; Microvascular Complications; Metabolic Memory; Adipose-tissue; In-vivo; Multifactorial Intervention
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2198-3844
e-ISSN 2198-3844
Journal Advanced science
Quellenangaben Volume: , Issue: , Pages: e2100275 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
Grants German Research Foundation (DFG)
Collaboration Research Center (CRC)
DOI 10.1002/advs.202100275
WOS ID WOS:000678065100001
Scopus ID 85111406627
PubMed ID 34319011
Erfassungsdatum 2021-08-06
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