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Emerging targets in type 2 diabetes and diabetic complications.
Adv. Sci., e2100275 (2021)
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications.
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Publication type
Article: Journal article
Document type
Review
Keywords
Insulin Resistance ; Metabolism ; Signaling Pathways ; Type 2 Diabetes, Diabetic Complications; Magnetic-resonance Neurography; Improves Insulin Sensitivity; Intensive Glucose Control; Beta-cell Dysfunction; Kidney-disease; Microvascular Complications; Metabolic Memory; Adipose-tissue; In-vivo; Multifactorial Intervention
ISSN (print) / ISBN
2198-3844
e-ISSN
2198-3844
Journal
Advanced science
Quellenangaben
Pages: e2100275
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
German Research Foundation (DFG)
Collaboration Research Center (CRC)
Collaboration Research Center (CRC)