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Meisinger, C. ; Freuer, D. ; Bub, A.* ; Linseisen, J.

Association between inflammatory markers and serum paraoxonase and arylesterase activities in the general population: A cross-sectional study.

Lipids Health Dis. 20:81 (2021)

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	Open Access Gold

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Background: Recent studies focused on modulating factors of paraoxonase-1 (PON1) activity. In some studies the association between pro-inflammatory markers and PON1 activity was examined, but so far no population-based investigations on this issue have been conducted. The present study investigated the relationships between the pro-inflammatory markers tumor necrosis factor (TNF)-α, leptin, interleukin (IL)-6, and high-sensitive C-reactive protein (hs-CRP) and paraoxonase and arylesterase, two hydrolytic activities of PON1, in the population-based Bavarian Food Consumption Survey II. Methods: Based on 504 participants (217 men, 287 women), the relationship between the pro-inflammatory markers and the outcomes paraoxonase and arylesterase activities were investigated using multivariable linear models. Results: Circulating plasma levels of leptin (P-value < 0.0001), hs-CRP (P-value = 0.031) and IL-6 (P-value = 0.045) were significantly non-linearly associated with arylesterase activity. Leptin levels were also significantly associated with paraoxonase activity (P-value = 0.024) independently from confounding factors, including high-density lipoprotein (HDL) cholesterol. With increasing levels of these inflammatory parameters, arylesterase and paraoxonase activities increased; however, at higher levels (> 75th percentile) the activities reached a plateau or even decreased somewhat. After Bonferroni-Holm correction, only leptin remained non-linearly but significantly associated with arylesterase activity (adjusted overall P-value < 0.0001). Neither age nor sex nor obesity modified the associations. No association was found between TNF-α and paraoxonase or arylesterase activity. Conclusions: The present findings suggest that in persons with very high levels of inflammation, PON1 activity may be impaired, a fact that might subsequently be accompanied by a higher risk for cardiometabolic diseases. Whether or not the measurement of PON1 activity in combination with a lipid profile and certain inflammatory markers could improve the prediction of cardiometabolic diseases in middle-aged individuals from the general population should be evaluated in clinical studies.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Arylesterase Activity ; Inflammation ; Oxidative Stress ; Paraoxonase Activity ; Pon1; C-reactive Protein; Antiinflammatory Properties; Density-lipoproteins; Oxidative Stress; Plasma-levels; Tnf-alpha; Leptin; Adiponectin; Obesity; Interleukin-6

ISSN (print) / ISBN 1476-511X

e-ISSN 1476-511X

Journal Lipids in Health and Disease

Quellenangaben Volume: 20, Issue: 1, Article Number: 81

Publisher Springer

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Independent Research Group Clinical Epidemiology (KEPI)

Grants Bayerisches Staatsministerium für Umwelt und Verbraucherschutz