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Trudzinski, F.C.* ; Kellerer, C.* ; Jörres, R.A.* ; Alter, P.* ; Lutter, J. ; Trinkmann, F.* ; Herth, F.J.F.* ; Frankenberger, M.* ; Watz, H.* ; Vogelmeier, C.F.* ; Kauczor, H.U.* ; Welte, T.* ; Behr, J.* ; Bals, R.* ; Kahnert, K.*

Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities.

Clin. Res. Cardiol., DOI: 10.1007/s00392-021-01915-x (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
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Background: In chronic obstructive pulmonary disease (COPD), gender-specific differences in the prevalence of symptoms and comorbidity are known. Research question: We studied whether the relationship between these characteristics depended on gender and carried diagnostic information regarding cardiac comorbidities. Study design and methods: The analysis was based on 2046 patients (GOLD grades 1–4, 795 women; 38.8%) from the COSYCONET COPD cohort. Assessments comprised the determination of clinical history, comorbidities, lung function, COPD Assessment Test (CAT) and modified Medical Research Council dyspnea scale (mMRC). Using multivariate regression analyses, gender-specific differences in the relationship between symptoms, single CAT items, comorbidities and functional alterations were determined. To reveal the relationship to cardiac disease (myocardial infarction, or heart failure, or coronary artery disease) logistic regression analysis was performed separately in men and women. Results: Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), differed significantly (p < 0.05) between men and women. Beyond this, the relationship between functional parameters and comorbidities versus symptoms showed gender-specific differences, especially for single CAT items. In men, item 8 (energy), mMRC, smoking status, BMI, age and spirometric lung function was related to cardiac disease, while in women primarily age was predictive. Interpretation: Gender-specific differences in COPD not only comprised differences in symptoms, comorbidities and functional alterations, but also differences in their mutual relationships. This was reflected in different determinants linked to cardiac disease, thereby indicating that simple diagnostic information might be used differently in men and women. Clinical trial registration: The cohort study is registered on ClinicalTrials.gov with identifier NCT01245933 and on GermanCTR.de with identifier DRKS00000284, date of registration November 23, 2010. Further information can be obtained on the website http://www.asconet.net.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cardiac Comorbidities ; Copd ; Copd Assessment Test ; Gender ; Symptoms; Obstructive Pulmonary-disease; Mortality; Risk
ISSN (print) / ISBN 1861-0684
e-ISSN 1861-0692
Journal Clinical Research in Cardiology
Publisher Springer
Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
Grants Teva GmbH
Projekt DEAL
BMBF Competence Network Asthma and COPD (ASCONET)
German Federal Ministry of Education and Research (BMBF)
DZL
AstraZeneca GmbH
Bayer Schering Pharma AG
Boehringer Ingelheim Pharma GmbH Co. KG
Chiesi GmbH
GlaxoSmithKline
Grifols Deutschland GmbH
MSD Sharp Dohme GmbH
Mundipharma GmbH
Novartis Deutschland GmbH
Pfizer Pharma GmbH
Takeda Pharma Vertrieb GmbH Co. KG