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Antigen-specific Treg therapy in type 1 diabetes - challenges and opportunities.
Front. Immunol. 12:712870 (2021)
Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment of autoimmune diseases given reduced side effects compared to general immunosuppressive therapies. However, the translation of antigen-specific Treg inducing therapies for the treatment or prevention of autoimmune diseases into the clinic remains challenging. In this mini review, we will discuss promising results for antigen-specific Treg therapies in allergy and specific challenges for such therapies in autoimmune diseases, with a focus on type 1 diabetes (T1D). We will furthermore discuss opportunities for antigen-specific Treg therapies in T1D, including combinatorial strategies and tissue-specific Treg targeting. Specifically, we will highlight recent advances in miRNA-targeting as a means to foster Tregs in autoimmunity. Additionally, we will discuss advances and perspectives of computational strategies for the detailed analysis of tissue-specific Tregs on the single-cell level.
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Publication type
Article: Journal article
Document type
Review
Keywords
T1d ; Tcr Specificity Prediction ; Antigen-specific Treg Therapy ; Autoimmunity ; Micrornas ; Single-cell Multi-omics Integration ; Tissue Tregs; Regulatory T-cells; Oral Insulin; High-risk; Expression; Immunotherapy; Heterogeneity; Autoimmunity; Prevention; Induction; Landscape
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 12,
Article Number: 712870
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Type 1 Diabetes Immunology (TDI)
Institute of Computational Biology (ICB)
Institute of Computational Biology (ICB)
Grants
EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2020
German Center for Diabetes Research (DZD)
Research Group at Helmholtz Zentrum Munchen
Helmholtz Association
Helmholtz Association under the joint research school "Munich School for Data Science
Deutsche Forschungsgemeinschaft (DFG)
Helmholtz Zentrum Munchen
German Center for Diabetes Research (DZD)
Research Group at Helmholtz Zentrum Munchen
Helmholtz Association
Helmholtz Association under the joint research school "Munich School for Data Science
Deutsche Forschungsgemeinschaft (DFG)
Helmholtz Zentrum Munchen