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Serr, I. ; Drost, F.* ; Schubert, B. ; Daniel, C.

Antigen-specific Treg therapy in type 1 diabetes - challenges and opportunities.

Front. Immunol. 12:712870 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment of autoimmune diseases given reduced side effects compared to general immunosuppressive therapies. However, the translation of antigen-specific Treg inducing therapies for the treatment or prevention of autoimmune diseases into the clinic remains challenging. In this mini review, we will discuss promising results for antigen-specific Treg therapies in allergy and specific challenges for such therapies in autoimmune diseases, with a focus on type 1 diabetes (T1D). We will furthermore discuss opportunities for antigen-specific Treg therapies in T1D, including combinatorial strategies and tissue-specific Treg targeting. Specifically, we will highlight recent advances in miRNA-targeting as a means to foster Tregs in autoimmunity. Additionally, we will discuss advances and perspectives of computational strategies for the detailed analysis of tissue-specific Tregs on the single-cell level.
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Publication type Article: Journal article
Document type Review
Keywords T1d ; Tcr Specificity Prediction ; Antigen-specific Treg Therapy ; Autoimmunity ; Micrornas ; Single-cell Multi-omics Integration ; Tissue Tregs; Regulatory T-cells; Oral Insulin; High-risk; Expression; Immunotherapy; Heterogeneity; Autoimmunity; Prevention; Induction; Landscape
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 12, Issue: , Pages: , Article Number: 712870 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Research Unit Type 1 Diabetes Immunology (TDI)
Institute of Computational Biology (ICB)
POF-Topic(s) 30201 - Metabolic Health
30205 - Bioengineering and Digital Health
Research field(s) Helmholtz Diabetes Center
Enabling and Novel Technologies
PSP Element(s) G-502191-001
G-503800-001
Grants EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2020
German Center for Diabetes Research (DZD)
Research Group at Helmholtz Zentrum Munchen
Helmholtz Association
Helmholtz Association under the joint research school "Munich School for Data Science
Deutsche Forschungsgemeinschaft (DFG)
Helmholtz Zentrum Munchen
DOI 10.3389/fimmu.2021.712870
WOS ID WOS:000689519900001
Scopus ID 85112591573
PubMed ID 34367177
Erfassungsdatum 2021-09-15
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