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Siehler, J. ; Blöchinger, A. ; Meier, M. ; Lickert, H.

Engineering islets from stem cells for advanced therapies of diabetes.

Nat. Rev. Drug Discov. 20, 920–940 (2021)
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Open Access Green
Diabetes mellitus is a metabolic disorder that affects more than 460 million people worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas type 2 diabetes (T2D) is caused by a hostile metabolic environment that leads to β-cell exhaustion and dysfunction. Currently, first-line medications treat the symptomatic insulin resistance and hyperglycaemia, but do not prevent the progressive decline of β-cell mass and function. Thus, advanced therapies need to be developed that either protect or regenerate endogenous β-cell mass early in disease progression or replace lost β-cells with stem cell-derived β-like cells or engineered islet-like clusters. In this Review, we discuss the state of the art of stem cell differentiation and islet engineering, reflect on current and future challenges in the area and highlight the potential for cell replacement therapies, disease modelling and drug development using these cells. These efforts in stem cell and regenerative medicine will lay the foundations for future biomedical breakthroughs and potentially curative treatments for diabetes.
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Publication type Article: Journal article
Document type Review
Keywords Insulin-producing Cells; Pancreatic Beta-cells; Mesenchymal Stromal Cells; Development Success Rates; In-vitro; Progenitor Cells; Alpha-cell; Endocrine Pancreas; Edmonton Protocol; Secreting Cells
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1474-1776
Journal Nature Reviews - Drug Discovery
Quellenangaben Volume: 20, Issue: , Pages: 920–940 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
Helmholtz Pioneer Campus (HPC)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
Pioneer Campus
PSP Element(s) G-502300-001
G-510002-001
Grants Technical University Munich
Helmholtz Association
German Center for Diabetes Research (DZD e.V.)
German Federal Ministry of Education and Research (BMBF)
European Union
DOI 10.1038/s41573-021-00262-w
WOS ID WOS:000683643300001
Scopus ID 85112200950
PubMed ID 34376833
Erfassungsdatum 2021-09-20
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