Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.
J. Neurosci. 30, 16949-16958 (2010)
Increased vulnerability to aversive experiences is one of the main risk factors for stress-related psychiatric disorders as major depression. However, the molecular bases of vulnerability, on the one hand, and stress resilience, on the other hand, are still not understood. Increasing clinical and preclinical evidence suggests a central involvement of the glutamatergic system in the pathogenesis of major depression. Using a mouse paradigm, modeling increased stress vulnerability and depression-like symptoms in a genetically diverse outbred strain, and we tested the hypothesis that differences in AMPA receptor function may be linked to individual variations in stress vulnerability. Vulnerable and resilient animals differed significantly in their dorsal hippocampal AMPA receptor expression and AMPA receptor binding. Treatment with an AMPA receptor potentiator during the stress exposure prevented the lasting effects of chronic social stress exposure on physiological, neuroendocrine, and behavioral parameters. In addition, spatial short-term memory, an AMPA receptor-dependent behavior, was found to be predictive of individual stress vulnerability and response to AMPA potentiator treatment. Finally, we provide evidence that genetic variations in the AMPA receptor subunit GluR1 are linked to the vulnerable phenotype. Therefore, we propose genetic variations in the AMPA receptor system to shape individual stress vulnerability. Those individual differences can be predicted by the assessment of short-term memory, thereby opening up the possibility for a specific treatment by enhancing AMPA receptor function.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
MAJOR DEPRESSIVE DISORDER; SPATIAL WORKING-MEMORY; POTENTIATORS LY392098; SYNAPTIC PLASTICITY; CELL-PROLIFERATION; MOOD DISORDERS; LONG-TERM; IN-VITRO; GLUTAMATE; EXPRESSION
ISSN (print) / ISBN
0270-6474
e-ISSN
1529-2401
Journal
Journal of Neuroscience
Quellenangaben
Volume: 30,
Issue: 50,
Pages: 16949-16958
Publisher
Society for Neuroscience
Publishing Place
Washington DC
Non-patent literature
Publications
Reviewing status
Peer reviewed