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Different responses of the oral, nasal and lung microbiomes to cigarette smoke.
Thorax 8, DOI: 10.1136/thoraxjnl-2020-216153 (2021)
To examine the role of smoking on the bacterial community composition of the upper and the lower respiratory tract, a monocentric, controlled prospective study was performed, including healthy smokers, ex-smokers and never-smokers. Smokers were further grouped according to their smoking history. Bacterial diversity was analysed using a molecular barcoding approach based on directly extracted DNA. Our study shows for the first time distinct bacterial response patterns in the upper and lower respiratory tract to cigarette smoking leading to a higher abundance of opportunistic pathogens. The clinical significance of these dysbioses for health needs to be further explored.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Tobacco And The Lung
ISSN (print) / ISBN
0040-6376
e-ISSN
1468-3296
Journal
Thorax
Quellenangaben
Volume: 8
Publisher
BMJ Publishing Group
Publishing Place
British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Comparative Microbiome Analysis (COMI)
Grants
Leibniz Competition 2016, 'The lung microbiota at the interface between airway epithelium and environment'