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Spears, E.* ; Serafimidis, I.* ; Powers, A.C.* ; Gavalas, A.

Debates in pancreatic beta cell biology: Proliferation versus progenitor differentiation and transdifferentiation in restoring β cell mass.

Front. Endocrin. 12:722250 (2021)

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In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancreatic cells for regeneration or replenishment is a critical need. Diverse lines of research have shown the capacity of endocrine as well as acinar, ductal and centroacinar cells to generate new β cells. Several experimental approaches using injury models, pharmacological or genetic interventions, isolation and in vitro expansion of putative progenitors followed by transplantations or a combination thereof have suggested several pathways for β cell neogenesis or regeneration. The experimental results have also generated controversy related to the limitations and interpretation of the experimental approaches and ultimately their physiological relevance, particularly when considering differences between mouse, the primary animal model, and human. As a result, consensus is lacking regarding the relative importance of islet cell proliferation or progenitor differentiation and transdifferentiation of other pancreatic cell types in generating new β cells. In this review we summarize and evaluate recent experimental approaches and findings related to islet regeneration and address their relevance and potential clinical application in the fight against diabetes.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Acinar Cells ; Centroacinar Cells ; Differentiation ; Duct Cells ; Transdifferentiation ; β Cell Proliferation ; β Cells; 60-percent Partial-pancreatectomy; Epidermal-growth-factor; Endocrine Pancreas; Duct Cells; Insulin-secretion; Exocrine Cells; Human Islets; Alpha-cells; Centroacinar Cells; Adult Exocrine

ISSN (print) / ISBN 1664-2392

e-ISSN 1664-2392

Journal Frontiers in Endocrinology

Quellenangaben Volume: 12, Article Number: 722250

Publisher Frontiers

Publishing Place Lausanne

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Pancreatic Islet Research (IPI)

Grants Leona M. and Harry B. Helmsley Charitable Trust
Department of Veterans Affairs
German Center for Diabetes Research (DZD)
German Research Foundation (DFG)
Greek General Secreteriat of Research and Technology (GSRT)
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Diabetes and Digestive and Kidney Diseases [the Human Islet Research Network (HIRN)]