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Hu, Y.* ; Ciminieri, C.* ; Hu, Q. ; Lehmann, M. ; Königshoff, M. ; Gosens, R.*

WNT signalling in lung physiology and pathology.

In:. Berlin ; Heidelberg: Springer, 2021. 305-336 (Handb. Exp. Pharmacol. ; 269)
Postprint DOI PMC
Open Access Green
The main physiological function of the lung is gas exchange, mediated at the interface between the alveoli and the pulmonary microcapillary network and facilitated by conducting airway structures that regulate the transport of these gases from and to the alveoli. Exposure to microbial and environmental factors such as allergens, viruses, air pollution, and smoke contributes to the development of chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. Respiratory diseases as a cluster are the commonest cause of chronic disease and of hospitalization in children and are among the three most common causes of morbidity and mortality in the adult population worldwide. Many of these chronic respiratory diseases are associated with inflammation and structural remodelling of the airways and/or alveolar tissues. They can often only be treated symptomatically with no disease-modifying therapies that normalize the pathological tissue destruction driven by inflammation and remodelling. In search for novel therapeutic strategies for these diseases, several lines of evidence revealed the WNT pathway as an emerging target for regenerative strategies in the lung. WNT proteins, their receptors, and signalling effectors have central regulatory roles under (patho)physiological conditions underpinning lung function and (chronic) lung diseases and we summarize these roles and discuss how pharmacological targeting of the WNT pathway may be utilized for the treatment of chronic lung diseases.
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Publication type Article: Edited volume or book chapter
Corresponding Author
Keywords Ageing ; Asthma ; Copd ; Fibrosis ; Lung ; Lung Cancer ; Regeneration ; Wnt
ISSN (print) / ISBN 0171-2004
Journal Handbook of Experimental Pharmacology
Quellenangaben Volume: 269, Issue: , Pages: 305-336 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Lung Repair and Regeneration (LRR)