PuSH - Publication Server of Helmholtz Zentrum München: Expression of the adipocyte progenitor markers <em>MSCA1</em> and <em>CD36</em> is associated with adipose tissue function in children.

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Hanschkow, M.* ; Boulet, N.* ; Kempf, E.* ; Bouloumié, A.* ; Kiess, W.* ; Stein, R. ; Körner, A.* ; Landgraf, K.*

Expression of the adipocyte progenitor markers MSCA1 and CD36 is associated with adipose tissue function in children.

J. Clin. Endocrinol. Metab. 107, e836-e851 (2022)

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CONTEXT: MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. OBJECTIVE: With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. METHODS: We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro, i.e. proliferation, differentiation and mitochondrial function. RESULTS: Both, MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction, i.e. adipocyte hypertrophy and serum hs-CRP, and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. CONCLUSION: In conclusion, both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Adipocyte Differentiation ; Adipocyte Progenitor Cells ; Adipose Tissue ; Adipose Tissue Dysfunction ; Children ; Obesity; Alkaline-phosphatase; Insulin-resistance; Gene-expression; Stromal Cells; Differentiation; Inflammation; Adolescents; Activation; Fat/cd36; Protein

ISSN (print) / ISBN 0021-972X

e-ISSN 1945-7197

Journal Journal of Clinical Endocrinology & Metabolism, The

Quellenangaben Volume: 107, Issue: 2, Pages: e836-e851

Publisher Endocrine Society

Publishing Place Bethesda, Md.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)

Grants ESPE Early Career Scientific Development
Federal Ministry of Education and Research (BMBF), Germany
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)