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Jiang, D. ; Rinkevich, Y.

Furnishing wound repair by the subcutaneous fascia.

Int. J. Mol. Sci. 22:9006 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia's unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Fascia ; Fibrosis ; Scar ; Skin ; Subcutaneous Fascia ; Superficial Fascia ; Wound Healing; Neuropathic Diabetic-patients; Granulation-tissue; Connective-tissue; Hypertrophic Scar; Skin; Regeneration; Hyaluronan; Mechanotransduction; Acupuncture; Fibroblasts
ISSN (print) / ISBN 1422-0067
e-ISSN 1661-6596
Journal International Journal of Molecular Sciences
Quellenangaben Volume: 22, Issue: 16, Pages: , Article Number: 9006 Supplement: ,
Publisher MDPI
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Grants European Research Council
Deutsche Forschungsgemeinschaft
Human Frontier Science Program