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RNA velocity-current challenges and future perspectives.
Mol. Syst. Biol. 17:e10282 (2021)
RNA velocity has enabled the recovery of directed dynamic information from single-cell transcriptomics by connecting measurements to the underlying kinetics of gene expression. This approach has opened up new ways of studying cellular dynamics. Here, we review the current state of RNA velocity modeling approaches, discuss various examples illustrating limitations and potential pitfalls, and provide guidance on how the ensuing challenges may be addressed. We then outline future directions on how to generalize the concept of RNA velocity to a wider variety of biological systems and modalities.
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Publication type
Article: Journal article
Document type
Review
Keywords
Rna Velocity ; Challenges ; Dynamics ; Limitations ; Perspectives; Single-cell; Gene-expression
ISSN (print) / ISBN
1744-4292
e-ISSN
1744-4292
Journal
Molecular Systems Biology
Quellenangaben
Volume: 17,
Issue: 8,
Article Number: e10282
Publisher
EMBO Press
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
Grants
EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
National Science Foundation (NSF)
Helmholtz Association ()
Deutsche Forschungsgemeinschaft (DFG)
National Science Foundation (NSF)
Helmholtz Association ()
Deutsche Forschungsgemeinschaft (DFG)