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A new era of atopic eczema research: Advances and highlights.
Allergy, DOI: 10.1111/all.15058 (2021)
Atopic eczema (AE) is an inflammatory skin disease with involvement of genetic, immunological, and environmental factors. One hallmark of AE is a skin barrier disruption on multiple, highly interconnected levels: filaggrin mutations, increased skin pH, and a microbiome dysbiosis towards Staphylococcus aureus overgrowth are observed in addition to an abnormal type 2 immune response. Extrinsic factors seem to play a major role in the development of AE. As AE is a first step in the atopic march, its prevention and appropriate treatment is essential. Although standard therapy remains topical treatment, powerful systemic treatment options emerged in the last years. However, thorough endotyping of the individual patients is still required for ideal precision medicine approaches in the future. Therefore, novel microbial and immunological biomarkers were described recently for the prediction of disease development and treatment response. This review summarizes the current state of the art in AE research.
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Publication type
Article: Journal article
Document type
Review
Keywords
Atopic Dermatitis ; Biomarkers ; Personalized Medicine ; Therapy; Staphylococcus-aureus Colonization; Antimicrobial Peptides; European Guidelines; Immune-system; Skin Barrier; Bleach Baths; Dermatitis; Children; Association; Emollient
ISSN (print) / ISBN
0105-4538
e-ISSN
1398-9995
Journal
Allergy
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Environmental Medicine (IEM)