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Melum, E.* ; Franke, A.* ; Schramm, C.* ; Weismüller, T.J.* ; Gotthardt, D.N.* ; Offner, F.A.* ; Juran, B.D.* ; Laerdahl, J.K.* ; Labi, V.* ; Björnsson, E.* ; Weersma, R.K.* ; Henckaerts, L.* ; Teufel, A.* ; Rust, C.* ; Ellinghaus, E.* ; Balschun, T.* ; Boberg, K.M.* ; Ellinghaus, D.* ; Bergquist, A.* ; Sauer, P.* ; Ryu, E.* ; Hov, J.R.* ; Wedemeyer, J.* ; Lindkvist, B.* ; Wittig, M.* ; Porte, R.J.* ; Holm, K.* ; Gieger, C. ; Wichmann, H.-E. ; Stokkers, P.* ; Ponsioen, C.Y.* ; Runz, H.* ; Stiehl, A.* ; Wijmenga, C.* ; Sterneck, M.* ; Vermeire, S.* ; Beuers, U.* ; Villunger, A.* ; Schrumpf, E.* ; Lazaridis, K.N.* ; Manns, M.P.* ; Schreiber, S.* ; Karlsen, T.H.*

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

Nat. Genet. 43, 17-19 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10⁻¹⁶ and P = 4.1 × 10⁻⁸, respectively).
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Bowel-disease; Pathogenesis
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 43, Issue: 1, Pages: 17-19 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)