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Kilinc, E.* ; Schulz, S. ; Kuiper, G.J.* ; Spronk, H.M.H.* ; ten Cate, H.* ; Upadhyay, S.* ; Ganguly, K.* ; Stöger, T. ; Semmler-Behnke, M. ; Takenaka, S. ; Kreyling, W.G. ; Pitz, M. ; Reitmeir, P. ; Peters, A. ; Eickelberg, O. ; Wichmann, H.-E.

The procoagulant effects of fine particulate matter in vivo.

Part. Fibre Toxicol. 8:12 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.
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Publication type Article: Journal article
Document type Letter to the Editor
Corresponding Author
Keywords CARDIOVASCULAR-DISEASE; AIR-POLLUTION; HEALTHY MICE; INFLAMMATION; PARTICLES; ASSOCIATION; COAGULATION; PULMONARY; EXPOSURE; RATS
ISSN (print) / ISBN 1743-8977
e-ISSN 1743-8977
Journal Particle and Fibre Toxicology
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 12 Supplement: ,
Publisher BioMed Central
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)
Institute of Health Economics and Health Care Management (IGM)