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Kilinc, E.* ; Schulz, S. ; Kuiper, G.J.* ; Spronk, H.M.H.* ; ten Cate, H.* ; Upadhyay, S.* ; Ganguly, K.* ; Stöger, T. ; Semmler-Behnke, M. ; Takenaka, S. ; Kreyling, W.G. ; Pitz, M. ; Reitmeir, P. ; Peters, A. ; Eickelberg, O. ; Wichmann, H.-E.

The procoagulant effects of fine particulate matter in vivo.

Part. Fibre Toxicol. 8:12 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.
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Publication type Article: Journal article
Document type Letter to the Editor
Keywords CARDIOVASCULAR-DISEASE; AIR-POLLUTION; HEALTHY MICE; INFLAMMATION; PARTICLES; ASSOCIATION; COAGULATION; PULMONARY; EXPOSURE; RATS
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 1743-8977
e-ISSN 1743-8977
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 12 Supplement: ,
Publisher Biomed Central
Publishing Place London
Reviewing status Peer reviewed
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
Lung Research
PSP Element(s) G-503900-001
G-504000-001
G-505000-001
G-505000-009
G-505000-002
G-505300-002
G-501600-001
PubMed ID 21406084
Scopus ID 79952557301
Erfassungsdatum 2011-05-24