PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Rocchi, A.* ; Carminati, E.* ; De Fusco, A.* ; Kowalska, J.A.* ; Floss, T. ; Benfenati, F.*

REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons.

Aging Cell, DOI: 10.1111/acel.13471:e13471 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
During aging, brain performances decline. Cellular senescence is one of the aging drivers and a key feature of a variety of human age-related disorders. The transcriptional repressor RE1-silencing transcription factor (REST) has been associated with aging and higher risk of neurodegenerative disorders. However, how REST contributes to the senescence program and functional impairment remains largely unknown. Here, we report that REST is essential to prevent the senescence phenotype in primary mouse neurons. REST deficiency causes failure of autophagy and loss of proteostasis, increased oxidative stress, and higher rate of cell death. Re-establishment of autophagy reverses the main hallmarks of senescence. Our data indicate that REST has a protective role in physiological aging by regulating the autophagic flux and the senescence program in neurons, with implications for neurological disorders associated with aging.
Impact Factor
Scopus SNIP
Altmetric
9.304
1.713
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Autophagy ; Mitochondria ; Neurons ; Oxidative Stress ; Rapamycin ; Rest/nrsf ; Senescence ; Trehalose; Rest; Abnormalities; Activation; Features
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1474-9718
e-ISSN 1474-9726
Journal Aging Cell
Quellenangaben Volume: , Issue: , Pages: , Article Number: e13471 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
Grants Compagnia di San Paolo Torino
Ministero Istruzione, Universita e Ricerca
Ministero della Salute Ricerca Finalizzata
DOI 10.1111/acel.13471
WOS ID WOS:000695631100001
Scopus ID 85114795523
PubMed ID 34520100
Erfassungsdatum 2021-10-11
[➜Report correction]