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T-cell‒mediated autoimmunity: Mechanisms and future directions.
J. Invest. Dermatol. 142, 804-810 (2022)
Publ. Version/Full Text
DOI
PMC
T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in producing autoantibodies. Technological advances have contributed to identifying autoantigens, the Holy Grail of autoimmunity, in many inflammatory disorders of the skin. Novel therapeutic approaches such as chimeric (auto)antibody receptor T cells are a milestone on the way to finding individualized, well-tolerated, targeted therapies. This review summarizes the current knowledge on pathogenesis, immune response pattern‒related ontology, diagnostic approaches, and treatment options of autoimmune skin diseases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Atopic-dermatitis; Interferon-gamma; Alopecia-areata; Ifn-gamma; Tetramer Technology; Th17 Cells; Skin; Psoriasis; Antigen; Ige
ISSN (print) / ISBN
0022-202X
e-ISSN
1523-1747
Quellenangaben
Volume: 142,
Issue: 3 PT B,
Pages: 804-810
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)
Grants
European Research Council