PuSH - Publication Server of Helmholtz Zentrum München: Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population - The sedentary's heart: The Study of Health in Pomerania (SHIP).

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Markus, M.R.P.* ; Ittermann, T.* ; Drzyzga, C.J.* ; Bahls, M.* ; Schipf, S.* ; Siewert-Markus, U.* ; Baumeister, S. ; Schumacher, P.* ; Ewert, R.* ; Völzke, H.* ; Steinhagen-Thiessen, E.* ; Bülow, R.* ; Schunkert, H.* ; Vasan, R.S.* ; Felix, S.B.* ; Dörr, M.*

Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population - The sedentary's heart: The Study of Health in Pomerania (SHIP).

Prog. Cardiovasc. Dis. 68, 25-35 (2021)

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Open Access Green as soon as Postprint is submitted to ZB.

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BACKGROUND: The heart has the capacity to adapt to different demands. The pathophysiological mechanisms involved with sedentarism are not fundamentally the opposite of those related with physical activity and regular exercise. We investigated the impact of lower cardiorespiratory fitness (CRF) on heart's plasticity and function in a population-based setting. METHODS: We used data from 1165 participants (539 women; 46.3%) aged 21-81 years from two independent cohorts of the Study of Health in Pomerania (SHIP-2 and SHIP-TREND-0). We analyzed the cross-sectional associations of peak oxygen uptake (VO_2peak), determined by symptom-limited cardiopulmonary exercise testing, with structural and functional left ventricular (LV) and left atrial (LA) parameters determined by magnetic resonance imaging (MRI) using multivariable- adjusted linear regression models. RESULTS: A1 L/min lower VO_2peak was associated with a 10.5 g (95% confidence interval: 8.00 to 12.9; p < 0.001) lower LV mass, a 14.8 mL (10.9 to 18.6; p < 0.001) lower LV end-diastolic volume, a 0.29 mm (0.19 to 0.40; p < 0.001) lower LV wall-thickness, a 8.85 mL/beat (6.53 to 11.2; p < 0.001) lower LV stroke volume, a 0.42 L/min (0.25 to 0.60; p < 0.001) lower LV cardiac output and a 7.51 mL (3.88 to 11.1; p < 0.001) lower LA end-diastolic volume. Moreover, there were no associations with a concentric or eccentric remodeling and LV and LA ejection fraction. CONCLUSIONS: Lower CRF was associated with a smaller heart, LV wall-thickness and mass, LV and LA stroke volume and cardiac output. Conversely, there was no association with LA and LV ejection fraction. Our cross-sectional observations are consistent with cardiac adaptations reflecting reduced volume loading demands of a sedentary lifestyle - "the sedentary's heart".

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Fat-free Mass ; Left Ventricular Geometry And Function ; Left Ventricular Mass ; Magnetic Resonance Imaging ; Peak Oxygen Uptake ; Physical Activity ; Remodeling ; Sedentarism ; Vo(2peak); Body-composition; Physical-activity; Blood-volume; Exercise; Failure; Age; Determinants; Mortality; Health; Region

ISSN (print) / ISBN 0033-0620

e-ISSN 1532-8643

Journal Progress in Cardiovascular Diseases

Quellenangaben Volume: 68, Pages: 25-35

Publisher Elsevier

Publishing Place 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Independent Research Group Clinical Epidemiology (KEPI)