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Ihantola, T.* ; Hirvonen, M.R.* ; Ihalainen, M.* ; Hakkarainen, H.* ; Sippula, O.* ; Tissari, J.* ; Bauer, S. ; Di Bucchianico, S. ; Rastak, N. ; Hartikainen, A.* ; Leskinen, J.* ; Yli-Pirilä, P.* ; Martikainen, M.V.* ; Miettinen, M.* ; Suhonen, H.* ; Rönkkö, T.J.* ; Kortelainen, M.* ; Lamberg, H.* ; Czech, H. ; Martens, P.* ; Orasche, J. ; Michalke, B. ; Yildirim, A.Ö. ; Jokiniemi, J.* ; Zimmermann, R. ; Jalava, P.I.*

Genotoxic and inflammatory effects of spruce and brown coal briquettes combustion aerosols on lung cells at the air-liquid interface.

Sci. Total Environ. 806:150489 (2022)
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Solid fuel usage in residential heating and cooking is one of the largest sources of ambient and indoor air particulate matter, which causes adverse effects on the health of millions of peoples worldwide. Emissions from solid fuel combustion, such as biomass or coal, are detrimental to health, but toxicological responses are largely unknown. In the present study, we compared the toxicological responses regarding cytotoxicity, inflammation and genotoxicity of spruce (SPR) and brown coal briquette (BCB) combustion aerosols on human alveolar epithelial cells (A549) as well as a coculture of A549 and differentiated human monocytic cells (THP-1) into macrophages exposed at the air-liquid interface (ALI). We included both the high emissions from the first hour and moderate emissions from the third hour of the batch combustion experiment in one ALI system, whereas, in the second ALI system, we exposed the cells during the whole 4-hour combustion experiment, including all combustion phases. Physico-chemical properties of the combustion aerosol were analysed both online and offline. Both SPR and BCB combustion aerosols caused mild cytotoxic but notable genotoxic effects in co-cultured A549 cells after one-hour exposure. Inflammatory response analysis revealed BCB combustion aerosols to cause a mild increase in CXCL1 and CXCL8 levels, but in the case of SPR combustion aerosol, a decrease compared to control was observed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ali ; Cytotoxicity ; Genotoxicity ; Inflammation ; Pm; Fly-ash Particles; Particulate Matter Pollution; In-vitro Cytotoxicity; Nf-kappa-b; Dna-damage; Wood Combustion; Diesel Fuel; Emissions; Exposure; Health
Language english
Publication Year 2022
Prepublished in Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0048-9697
e-ISSN 1879-1026
Journal Science of the Total Environment, The
Quellenangaben Volume: 806, Issue: Pt 1, Pages: , Article Number: 150489 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Cooperation Group Comprehensive Molecular Analytics (CMA)
Research Unit BioGeoChemistry and Analytics (BGC)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
Lung Research
PSP Element(s) G-504500-001
G-504800-002
G-505000-007
Grants Finnish Cultural Foundation
HGF
LifeScience-Stiftung zur Forderung von Wissenschaft und Forschung
Helmholtz Zentrum Munchen (INHALE-HICE Project)
Doctoral School of University of Eastern Finland
Academy of Finland
Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health (HICE) via the Helmholtz Association of German Research Centers (HGF)
DOI 10.1016/j.scitotenv.2021.150489
WOS ID WOS:000707657300001
Scopus ID 85115886508
PubMed ID 34844316
Erfassungsdatum 2021-11-15
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