PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Kabiri, Y.* ; Fuhrmann, A. ; Becker, A. ; Jedermann, L. ; Eberhagen, C. ; König, A. ; Silva, T.B.* ; Borges, F.* ; Hauck, S.M. ; Michalke, B. ; Knolle, P.* ; Zischka, H.

Mitochondrial impairment by MitobloCK-6 inhibits liver cancer cell proliferation. 

Front. Cell Dev. Biol. 9:725474 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. These effects were mostly reversed by supplementation with bioavailable hemin b, linking ALR function to mitochondrial iron homeostasis. Since many tumor cells are known for their increased iron demand and since increased iron levels in cancer are associated with poor clinical outcome, these results help to further advance the intricate relation between iron and mitochondrial homeostasis in liver cancer.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.684
1.283
1
2
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Mitochondria ; Hcc ; Disulfide Relay System ; Iron ; Heme; Sulfhydryl Oxidase; Intermembrane Space; Protein; Expression; Iron; Regeneration; Metabolism; Maturation; Sorafenib; Induction
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2296-634X
e-ISSN 2296-634X
Journal Frontiers in cell and developmental biology
Quellenangaben Volume: 9, Issue: , Pages: , Article Number: 725474 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Health Economics and Health Care Management (IGM)
CF Metabolomics & Proteomics (CF-MPC)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30202 - Environmental Health
Research field(s) Enabling and Novel Technologies
Genetics and Epidemiology
Environmental Sciences
PSP Element(s) G-505200-003
G-505200-001
G-505300-001
G-505700-001
G-504800-002
Grants FEDER/COMPETE
Foundation for Science and Technology (FCT)
European Unions Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant
DOI 10.3389/fcell.2021.725474
WOS ID WOS:000703078100001
Scopus ID 85116491049
PubMed ID 34616733
Erfassungsdatum 2021-10-18
[➜Report correction]