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Winheim, E.* ; Rinke, L.* ; Lutz, K.* ; Reischer, A.* ; Leutbecher, A.* ; Wolfram, L.* ; Rausch, L.* ; Kranich, J.* ; Wratil, P.R.* ; Huber, J.E.* ; Baumjohann, D.* ; Rothenfußer, S. ; Schubert, B. ; Hilgendorff, A. ; Hellmuth, J.C.* ; Scherer, C.* ; Muenchhoff, M.* ; von Bergwelt-Baildon, M.* ; Stark, K.* ; Straub, T.* ; Brocker, T.* ; Keppler, O.T.* ; Subklewe, M.* ; Krug, A.B.*

Impaired function and delayed regeneration of dendritic cells in COVID-19.

PLoS Pathog. 17:e1009742 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage-HLADR+ cells lacking DC markers. Increased frequency of CD163+ CD14+ cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naïve CD4+ T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Infection; Mild; Population; Sars-cov-2; Responses; Melanoma; Immunity; Subsets; Reveals
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1553-7366
e-ISSN 1553-7374
Journal PLoS Pathogens
Quellenangaben Volume: 17, Issue: 10, Pages: , Article Number: e1009742 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place 1160 Battery Street, Ste 100, San Francisco, Ca 94111 Usa
Reviewing status Peer reviewed
Institute(s) Unit for Clinical Pharmacology (KKG-EKLiP)
Institute of Computational Biology (ICB)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30205 - Bioengineering and Digital Health
30202 - Environmental Health
Research field(s) Immune Response and Infection
Enabling and Novel Technologies
Lung Research
PSP Element(s) G-522100-001
G-503800-001
G-552100-001
Grants Wilhelm Sander Stiftung
Bavarian Elite Graduate Training Network
Villigst Foundation
Bavarian State Ministry of Science and the Arts
Else-Kroner-FreseniusStiftung
Germany's Excellence Strategy EXC2151
'Deutsche Forschungsgemeinschaft'
Faculty of Medicine of the LMU Munchen
Free State of Bavaria under the Excellence Strategy of the Federal Government and the States
LMUexcellent
Federal Ministry of Education and Research (BMBF) initiative "NaFoUniMedCovid19"
Federal Ministry of Education and Research (BMBF) initiative "COMBAT C19IR"
Deutsche Forschungsgemeinschaft
DOI 10.1371/journal.ppat.1009742
WOS ID WOS:000721615300001
Scopus ID 85116934401
PubMed ID 34614036
Erfassungsdatum 2021-12-07
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