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Wagner, R. ; Eckstein, S.S. ; Yamazaki, H.* ; Gerst, F. ; Machann, J. ; Jaghutriz, B.A. ; Schürmann, A.* ; Solimena, M. ; Singer, S.R.* ; Königsrainer, A.* ; Birkenfeld, A.L. ; Häring, H.-U. ; Fritsche, A. ; Ullrich, S. ; Heni, M.

Metabolic implications of pancreatic fat accumulation.

Nat. Rev. Endocrinol. 18, 43–54 (2022)
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Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.
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Publication type Article: Journal article
Document type Review
Keywords Beta-cell Function; Stimulated Insulin-secretion; Fetuin-a; Cystic-fibrosis; Adipose-tissue; Hyperechogenic Pancreas; Quantitative Assessment; Clinical-significance; Increased Lipolysis; Bariatric Surgery
Language english
Publication Year 2022
Prepublished in Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Journal Nature Reviews - Endocrinology
Quellenangaben Volume: 18, Issue: , Pages: 43–54 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
G-502600-001
Grants JSPS KAKENHI
Federal Ministry of Education and Research (BMBF)
DOI 10.1038/s41574-021-00573-3
WOS ID WOS:000709265500001
Scopus ID 85117395885
PubMed ID 34671102
Erfassungsdatum 2021-10-27
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