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Wagner, R. ; Eckstein, S.S. ; Yamazaki, H.* ; Gerst, F. ; Machann, J. ; Jaghutriz, B.A. ; Schürmann, A.* ; Solimena, M. ; Singer, S.R.* ; Königsrainer, A.* ; Birkenfeld, A.L. ; Häring, H.-U. ; Fritsche, A. ; Ullrich, S. ; Heni, M.

Metabolic implications of pancreatic fat accumulation.

Nat. Rev. Endocrinol. 18, 43–54 (2022)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Beta-cell Function; Stimulated Insulin-secretion; Fetuin-a; Cystic-fibrosis; Adipose-tissue; Hyperechogenic Pancreas; Quantitative Assessment; Clinical-significance; Increased Lipolysis; Bariatric Surgery
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Journal Nature Reviews - Endocrinology
Quellenangaben Volume: 18, Issue: , Pages: 43–54 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute for Pancreatic Beta Cell Research (IPI)
Grants JSPS KAKENHI
Federal Ministry of Education and Research (BMBF)