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Li, W.B. ; Stangl, S.* ; Klapproth, A. ; Shevtsov, M.* ; Hernandez, A.* ; Kimm, M.A.* ; Schuemann, J.* ; Qiu, R.* ; Michalke, B. ; Bernal, M.A.* ; Li, J.* ; Hürkamp, K. ; Zhang, Y.* ; Multhoff, G.*

Application of high‐Z gold nanoparticles in targeted cancer radiotherapy—pharmacokinetic modeling, Monte Carlo simulation and radiobiological effect modeling.

Cancers 13:5370 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
High‐Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP‐conjugates in preclinical modeling of radiotherapy at the Klinikum rechts der Isar, Technical University of Munich and Helmholtz Zentrum München. A pharmacokinetic model of superparamagnetic iron oxide nanoparticles was developed in preparation for a model simulating.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cancers ; Gold Nanoparticles ; X-rays ; Cmhsp70.1 ; Conjugation ; Targeted Radiotherapy ; Enhancement Effect ; Pharmacokinetic Model ; Monte Carlo Simulation ; Radiobiological Modeling; Computed-tomography Xfct; Dose Enhancement Therapy; Dna-damage; In-vitro; X-rays; Heat-shock-protein-70 Hsp70; Secondary Electrons; Contrast Agents; Ion Irradiation; Cellular Uptake
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2072-6694
Journal Cancers
Quellenangaben Volume: 13, Issue: 21, Pages: , Article Number: 5370 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30202 - Environmental Health
Research field(s) Radiation Sciences
Environmental Sciences
PSP Element(s) G-501391-001
G-504800-002
Grants TUM Graduate School Internationalization Grant
Technische Universitat Munchen (TUM) within the DFG funding
Ministry of Science and Higher Education of The Russian Federation
National Institutes of Health (NIH)/National Cancer Institute (NCI)
FAPESP foundation in Brazil
CNPq
DFG
DOI 10.3390/cancers13215370
WOS ID WOS:000718542200001
Scopus ID 85117958253
PubMed ID 34771534
Erfassungsdatum 2021-12-15
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