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Li, W.B. ; Stangl, S.* ; Klapproth, A. ; Shevtsov, M.* ; Hernandez, A.* ; Kimm, M.A.* ; Schuemann, J.* ; Qiu, R.* ; Michalke, B. ; Bernal, M.A.* ; Li, J.* ; Hürkamp, K. ; Zhang, Y.* ; Multhoff, G.*

Application of high‐Z gold nanoparticles in targeted cancer radiotherapy—pharmacokinetic modeling, Monte Carlo simulation and radiobiological effect modeling.

Cancers 13:5370 (2021)

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	Open Access Gold

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High‐Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP‐conjugates in preclinical modeling of radiotherapy at the Klinikum rechts der Isar, Technical University of Munich and Helmholtz Zentrum München. A pharmacokinetic model of superparamagnetic iron oxide nanoparticles was developed in preparation for a model simulating.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cancers ; Gold Nanoparticles ; X-rays ; Cmhsp70.1 ; Conjugation ; Targeted Radiotherapy ; Enhancement Effect ; Pharmacokinetic Model ; Monte Carlo Simulation ; Radiobiological Modeling; Computed-tomography Xfct; Dose Enhancement Therapy; Dna-damage; In-vitro; X-rays; Heat-shock-protein-70 Hsp70; Secondary Electrons; Contrast Agents; Ion Irradiation; Cellular Uptake

ISSN (print) / ISBN 2072-6694

Journal Cancers

Quellenangaben Volume: 13, Issue: 21, Article Number: 5370

Publisher MDPI

Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Medicine (IRM)
Research Unit Analytical BioGeoChemistry (BGC)

Grants TUM Graduate School Internationalization Grant
Technische Universitat Munchen (TUM) within the DFG funding
Ministry of Science and Higher Education of The Russian Federation
National Institutes of Health (NIH)/National Cancer Institute (NCI)
FAPESP foundation in Brazil
CNPq
DFG