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Deshpande, S.S.* ; Malik, S.C.* ; Conforti, P.* ; Lin, J.d.* ; Chu, Y.H.* ; Nath, S.* ; Greulich, F. ; Dumbach, M.A.* ; Uhlenhaut, N.H. ; Schachtrup, C.*

P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.

Cell Tissue Res., DOI: 10.1007/s00441-021-03539-z (2021)
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Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ NSPC-redirected migration to the lesion area are poorly understood. Here, we show that genetic depletion of the p75 neurotrophin receptor (p75NTR−/−) in mice reduced SVZ NSPC migration towards the lesion area after cortical injury and that p75NTR−/− NSPCs failed to migrate upon BDNF stimulation in vitro. Cortical injury rapidly increased p75NTR abundance in SVZ NSPCs via bone morphogenetic protein (BMP) receptor signaling. SVZ-derived p75NTR−/− NSPCs revealed an altered cytoskeletal network- and small GTPase family-related gene and protein expression. In accordance, BMP-treated non-migrating p75NTR−/− NSPCs revealed an altered morphology and α-tubulin expression compared to BMP-treated migrating wild-type NSPCs. We propose that BMP-induced p75NTR abundance in NSPCs is a regulator of SVZ NSPC migration to the lesion area via regulation of the cytoskeleton following cortical injury.
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Publication type Article: Journal article
Document type Review
Keywords Bone Morphogenetic Protein ; Cytoskeleton ; Ischemic Stroke ; Neurotrophin Receptor ; Stem Cell Migration ; Vascular Damage; Adult Brain; Tgf-beta; Astrocytes; P75(ntr); Differentiation; Neurogenesis; Expression; Neurons; Niche; Precursors
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0044-3794
e-ISSN 1432-0878
Journal Cell and Tissue Research
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-227
Grants German Research Foundation
Deutscher Akademischer Austauschdienst fellowship
DOI 10.1007/s00441-021-03539-z
WOS ID WOS:000711345600001
Scopus ID 85118132749
PubMed ID 34698916
Erfassungsdatum 2021-11-18
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