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Khazaei, Y. ; Harris, C. ; Heinrich, J.* ; Standl, M. ; Kühnisch, J.*

Association study on nutrition in the first year of life and molar-incisor hypomineralization (Mih)—results from the giniplus and lisa birth cohort studies.

Int. J. Environ. Res. Public Health 18:11411 (2021)

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Molar-incisor hypomineralization (MIH) is a condition with specific clinical presentation whose etiology to date still remains unknown. This study prospectively investigated the association between nutrition during the 1st year of life and the presence of MIH in the permanent dentition. Data from 1070 10-year-old children from two prospective birth cohort studies were included. Information on exclusive breastfeeding (EBF) and introduction of 48 food items into the child’s diet was assessed at 4-, 6-, and 12-month time-points. Food diversity was defined according to the number of food items or food groups introduced into the child’s diet and then subsequent categorization into low-, middle-and high-diversity groups was performed. MIH was scored in the permanent dentition at age of 10 years. The statistical analysis included logistic and Poisson hurdle regression models adjusted for potential confounders. EBF, food item and food group diversity at 4-, 6-, 12-month time-points were found to be non-significant in most of the categories for the development of MIH. However, significantly higher odds for the presence of MIH were found for certain categories. Despite the limitation of this study, such as arbitrary cut-offs for categorization of food items, the results of this study suggest the lack of an association between early nutrition in the first year of life and MIH in the permanent dentition.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Aetiology Research ; Birth Cohort Study ; Developmental Enamel Defects ; Early Nutrition ; Epidemiology ; Exclusive Breastfeeding ; Molar-incisor Hypomineralization; Caries Experience; Etiology; Defects; Dioxins; Teeth; Mih

ISSN (print) / ISBN 1661-7827

e-ISSN 1660-4601

Journal International Journal of Environmental Research and Public Health

Quellenangaben Volume: 18, Issue: 21, Article Number: 11411

Publisher MDPI

Publishing Place Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)

Grants Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München
Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie
LMU Munich
Helmholtz-Zentrum für Umweltforschung
Institut Universitaire de France
'Deutsche Forschungsgemeinschaft' (DFG)
Technical University of Munich (TUM)
Marien-Hospital Wesel
IUF-Leibniz Research Institute for Environmental Medicine
Helmholtz Centre for Environ-mental Research-UFZ, Leipzig