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Evolutionary conservation and cell type specificity of nuclear compartments in the brain.
Trends Neurosci. 45, 3-5 (2021)
In the cell nucleus, radial genome organization relative to the nuclear lamina exhibits both cell type–specific variability and evolutionarily conserved distribution. A recent study by Ahanger, Delgado et al. explores the in vivo spatial distribution of the genome in the brain and identifies conserved genomic localization across mammalian species that are correlated with gene expression states.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Human Cortex ; Lamin B ; Lamina-associated Domain (lad) ; Spatial Genome Organization ; Speckle-associated Domain (spad); Organization; Dynamics
Language
english
Publication Year
2021
HGF-reported in Year
2021
ISSN (print) / ISBN
0166-2236
e-ISSN
1878-108X
Journal
Trends in Neurosciences
Quellenangaben
Volume: 45,
Issue: 1,
Pages: 3-5
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)
POF-Topic(s)
30204 - Cell Programming and Repair
30205 - Bioengineering and Digital Health
30205 - Bioengineering and Digital Health
Research field(s)
Pioneer Campus
PSP Element(s)
G-510004-001
G-510000-001
G-510000-001
Grants
Helmholtz Pioneer Campus
HelmholtzGemeinschaft
DFG
HelmholtzGemeinschaft
DFG
WOS ID
WOS:000734663800002
Scopus ID
85118261333
PubMed ID
34756461
Erfassungsdatum
2021-12-15