PuSH - Publication Server of Helmholtz Zentrum München: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Lin, W.Y.* ; Fordham, S.E.* ; Hungate, E.* ; Sunter, N.J.* ; Elstob, C.* ; Xu, Y.* ; Park, C.* ; Quante, A.S. ; Strauch, K. ; Gieger, C.* ; Skol, A.* ; Rahman, T.* ; Sucheston-Campbell, L.* ; Wang, J.* ; Hahn, T.* ; Clay-Gilmour, A.I.* ; Jones, G.L.* ; Marr, H.J.* ; Jackson, G.H.* ; Menne, T.* ; Collin, M.* ; Ivey, A.* ; Hills, R.K.* ; Burnett, A.K.* ; Russell, N.H.* ; Fitzgibbon, J.* ; Larson, R.A.* ; Le Beau, M.M.* ; Stock, W.* ; Heidenreich, O.* ; Alharbi, A.* ; Allsup, D.J.* ; Houlston, R.S.* ; Norden, J.* ; Dickinson, A.M.* ; Douglas, E.* ; Lendrem, C.* ; Daly, A.K.* ; Palm, L.* ; Piechocki, K.* ; Jeffries, S.* ; Bornhäuser, M.* ; Röllig, C.* ; Altmann, H.* ; Ruhnke, L.* ; Kunadt, D.* ; Wagenführ, L.* ; Cordell, H.J.* ; Darlay, R.* ; Andersen, M.K.* ; Fontana, M.C.* ; Martinelli, G.* ; Marconi, G.* ; Sanz, M.A.* ; Cervera, J.* ; Gómez-Seguí, I.* ; Cluzeau, T.* ; Moreilhon, C.* ; Raynaud, S.* ; Sill, H.* ; Voso, M.T.* ; Lo-Coco, F.* ; Dombret, H.* ; Cheok, M.* ; Preudhomme, C.* ; Gale, R.E.* ; Linch, D.* ; Gaal-Wesinger, J.* ; Masszi, A.* ; Nowak, D.* ; Hofmann, W.K.* ; Gilkes, A.* ; Porkka, K.* ; Milosevic Feenstra, J.D.* ; Kralovics, R.* ; Grimwade, D.* ; Meggendorfer, M.* ; Haferlach, T.* ; Krizsán, S.* ; Bödör, C.* ; Stölzel, F.* ; Onel, K.* ; Allan, J.M.*

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.

Nat. Commun. 12:6233 (2021)

Postprint

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10^-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10^-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Human-leukocyte Antigen; Immune Escape; Clonal Evolution; Gene-mutations; Older Patients; Risk; Cancer; Hla; Hif-1-alpha; Aml

ISSN (print) / ISBN 2041-1723

e-ISSN 2041-1723

Journal Nature Communications

Quellenangaben Volume: 12, Issue: 1, Article Number: 6233

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Genetic Epidemiology (IGE)

Grants Dr. Rolf M. Schwiete Fund, Mannheim
Hungarian National Research, Development and Innovation Office (NKFIH)
Hungarian Academy of Sciences
EU's Horizon 2020 research and innovation program
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, LMUinnovativ
Progetto AIRC 5permille Mynerva
Deutsche Jose Carreras Leukaemie Stiftung
H.W. & J. Hector fund, Baden Wuerttemberg
Blood Cancer UK