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Kunzke, T. ; Prade, V.M. ; Buck, A. ; Sun, N. ; Feuchtinger, A. ; Matzka, M. ; Fernandez, I.E.* ; Wuyts, W.A.* ; Ackermann, M.* ; Jonigk, D.* ; Aichler, M. ; Schmid, R.A.* ; Eickelberg, O.* ; Berezowska, S.* ; Walch, A.K.

Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology.

Cancer Res. 81, 5862-5875 (2021)

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Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiological significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorption/ionization (MALDI) fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging analysis, we discovered noxious carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines, or aromatic amines, in a series of 330 lung cancer patients in highly variable and unique patterns. The characteristic nature of carbon-bound exogenous compound had a strong association with patient outcome, tumor progression, the tumor immune microenvironment, PD-L1 expression, and DNA damage. Spatial correlation network analyses revealed substantial differences in the metabolome of tumor cells compared to tumor stroma depending on carbon-bound exogenous compounds. Overall, the bioactive pool of exogenous compounds is associated with several changes in lung cancer pathophysiology and correlates with patient outcome. Given the high prevalence of anthracosis in the lungs of adult humans, future work should investigate the role of carbon-bound exogenous compounds in lung carcinogenesis and lung cancer therapy.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Polycyclic Aromatic-hydrocarbons; Imaging Mass-spectrometry; Pulmonary-fibrosis; Retention; Particles; Smoking; Risk

ISSN (print) / ISBN 0008-5472

e-ISSN 1538-7445

Journal Cancer Research

Quellenangaben Volume: 81, Issue: 23, Pages: 5862-5875

Publisher American Association for Cancer Research (AACR)

Publishing Place Philadelphia, Pa.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Analytical Pathology (AAP)

Grants Helmholtz Zentrum Munchen
Impulse and Networking Fund of the Helmholtz Association
Deutsche Krebshilfe
Deutsche Forschungsgemeinschaft
Ministry of Education and Research of the Federal Republic of Germany (BMBF)