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Open Access Green as soon as Postprint is submitted to ZB.
From virus to inflammation: Mechanisms of RIG-I-induced IL-1β production.
Eur. J. Cell Biol. 91, 59-64 (2012)
Early detection of viruses by the innate immune system is critical for host defense. Antiviral immunity is initiated by germline encoded pattern recognition receptors (PRRs) that recognize viral pathogen-associated molecular patterns (PAMPs) such as nucleic acids. Intracellular PRRs then drive the production of interferons and cytokines to orchestrate immune responses. One key host factor that is critical for antiviral immunity and for systemic inflammatory reactions including fever is interleukin-1beta (IL-1β). Here we discuss current insights into the molecular mechanisms how the cytosolic RNA helicase RIG-I triggers NF-κB signaling and inflammasome activation specifically for RNA virus-induced IL-1β production.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
NOD like receptors; RIG-I-like helicases; CARD9; Inflammasome; NLRP3; IL-1β
ISSN (print) / ISBN
0171-9335
e-ISSN
1618-1298
Journal
European Journal of Cell Biology
Quellenangaben
Volume: 91,
Issue: 1,
Pages: 59-64
Publisher
Elsevier
Publishing Place
Jena, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed