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Neiburga, K.D.* ; Vilne, B.* ; Bauer, S.* ; Bongiovanni, D.* ; Ziegler, T.* ; Lachmann, M.* ; Wengert, S. ; Hawe, J.S.* ; Güldener, U.* ; Westerlund, A. ; Li, L.* ; Pang, S.* ; Yang, C.* ; Saar, K.* ; Huebner, N.* ; Maegdefessel, L.* ; Lange, R.* ; Krane, M.* ; Schunkert, H.* ; von Scheidt, M.*

Vascular tissue specific mirna profiles reveal novel correlations with risk factors in coronary artery disease.

Biomolecules 11, New Approaches for the Treatment of Civilization Diseases:1683 (2021)
Postprint Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microR-NAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from Arteria mammaria interna (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, p-value (p < 0.006, false discovery rate (FDR)
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Arteria Mammaria Interna ; Biomarker ; Biosensor ; Cardiovascular Disease ; Coronary Artery Bypass Grafting ; Coronary Artery Disease ; Local Therapy ; Micro Rna ; Personalized Medicine
ISSN (print) / ISBN 2218-273X
e-ISSN 2218-273X
Journal Biomolecules
Quellenangaben Volume: 11, Issue: 11, Pages: , Article Number: 1683, Supplement: New Approaches for the Treatment of Civilization Diseases
Publisher MDPI
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
Institute of Computational Biology (ICB)
Grants BMBF (German Federal Ministry of Education and Research)