Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Return to homeostasis: Downregulation of NF-κB responses.
Nat. Immunol. 12, 709-714 (2011)
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
t-cell-activation; alpha-mediated phosphorylation; negative feedback loop; editing enzyme a20; ikk-alpha; irak-m; deubiquitinating enzyme; gene-expression; innate immunity; signaling pathway
ISSN (print) / ISBN
1529-2908
e-ISSN
1529-2916
Journal
Nature Immunology
Quellenangaben
Volume: 12,
Issue: 8,
Pages: 709-714
Publisher
Nature Publishing Group
Publishing Place
New York, NY, USA
Reviewing status
Peer reviewed