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Return to homeostasis: Downregulation of NF-κB responses.
Nat. Immunol. 12, 709-714 (2011)
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
t-cell-activation; alpha-mediated phosphorylation; negative feedback loop; editing enzyme a20; ikk-alpha; irak-m; deubiquitinating enzyme; gene-expression; innate immunity; signaling pathway
ISSN (print) / ISBN
1529-2908
e-ISSN
1529-2916
Journal
Nature Immunology
Quellenangaben
Volume: 12,
Issue: 8,
Pages: 709-714
Publisher
Nature Publishing Group
Publishing Place
New York, NY, USA
Non-patent literature
Publications
Reviewing status
Peer reviewed