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Ruland, J.

Return to homeostasis: Downregulation of NF-κB responses.

Nat. Immunol. 12, 709-714 (2011)

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Open Access Green as soon as Postprint is submitted to ZB.

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Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.

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3.101

137

239