PuSH - Publication Server of Helmholtz Zentrum München: Blood immunoproteasome activity is regulated by sex, age and in chronic inflammatory diseases: A first population-based study.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Kammerl, I.E. ; Flexeder, C. ; Karrasch, S. ; Thorand, B. ; Heier, M. ; Peters, A. ; Schulz, H. ; Meiners, S.

Blood immunoproteasome activity is regulated by sex, age and in chronic inflammatory diseases: A first population-based study.

Cells 10:3336 (2021)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Dysfunction of the immunoproteasome has been implicated in cardiovascular and pulmonary diseases. Its potential as a biomarker for predicting disease stages, however, has not been investigated so far and population-based analyses on the impact of sex and age are missing. We here analyzed the activity of all six catalytic sites of the proteasome in isolated peripheral blood mononuclear cells obtained from 873 study participants of the KORA FF4 study using activity-based probes. The activity of the immuno-and standard proteasome correlated clearly with elevated leukocyte counts of study participants. Unexpectedly, we observed a strong sex dimorphism for proteasome activity with significantly lower immunoproteasome activity in women. In aging, almost all catalytic activities of the proteasome were activated in aged women while maintained upon aging in men. We also noted distinct sex-related activation patterns of standard and immunoproteasome active sites in chronic inflammatory diseases such as diabetes, cardiovascular diseases, asthma, or chronic obstructive pulmonary disease as determined by multiple linear regression modeling. Our data thus provides a conceptual framework for future analysis of immunoproteasome function as a bio-marker for chronic inflammatory disease development and progression.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Age ; Asthma ; Cardiovascular Disease ; Chronic Obstructive Pulmonary Disease (copd) ; Diabetes ; Immunoproteasome ; Peripheral Blood Mononuclear Cells ; Population-based Study ; Sex; Ubiquitin-proteasome System; Reticulum Stress-response; Plasma Immunoproteasome; Oxidative Stress; Subunit Lmp2; Transcriptome; Degradation; Dysfunction; Inhibition; Expression

ISSN (print) / ISBN 2073-4409

e-ISSN 2073-4409

Journal Cells

Quellenangaben Volume: 10, Issue: 12, Article Number: 3336

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Institute(s) Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)

Grants Helmholtz Zentrum Munchen - German Research Center for Environmental Health