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Kemp, C.G.* ; Johnson, L.C.M.* ; Sagar, R.* ; Poongothai, S.* ; Tandon, N.* ; Anjana, R.M.* ; Aravind, S.* ; Sridhar, G.R.* ; Patel, S.A.* ; Emmert-Fees, K. ; Rao, D.* ; Narayan, K.M.V.* ; Mohan, V.* ; Ali, M.K.* ; Chwastiak, L.A.*

Effect of a collaborative care model on anxiety symptoms among patients with depression and diabetes in India: The INDEPENDENT randomized clinical trial.

Gen. Hosp. Psychiatry 74, 39-45 (2022)
Postprint DOI PMC
Open Access Green
Objective: We assessed the impact of a collaborative care intervention on anxiety symptoms among participants in India with comorbid depression, poorly controlled diabetes, and moderate to severe anxiety symptoms. Method: We analyzed data from a randomized controlled trial conducted at four diabetes clinics in India. Participants received either collaborative care or usual care. We included only participants who scored ⩾10 on the Generalized Anxiety Disorder-7 (GAD-7) at baseline. We estimated the effect of the intervention on clinically significant reduction in anxiety symptoms; we considered several potential baseline moderators and mediation by anti-depressant use. Results: One hundred and seventy-two participants scored 10 or above on the GAD-7 at baseline. Collaborative care participants were more likely than control participants to achieve a clinically significant reduction in anxiety symptoms at 6 and 12 months (65.7% vs. 41.4% at 12 months, p = 0.002); these differences were not sustained at 18 or 24 months. There was little evidence of moderation by participant characteristics at baseline, and effects were not mediated by anti-depressant use. Conclusions: Collaborative care for the treatment of depression and type 2 diabetes can lead to clinically significant reductions in anxiety symptoms among patients with anxiety. Effects were notable during the active intervention period but not over the year post-intervention.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Anxiety ; Collaborative Care ; Depression ; Diabetes ; India ; Integrated Care; Disorders; Prevalence; Adults; Management; Impact
ISSN (print) / ISBN 0163-8343
e-ISSN 1873-7714
Journal General hospital psychiatry
Quellenangaben Volume: 74, Issue: , Pages: 39-45 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
Grants National Institute of Mental Health