PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Schlosser, P.* ; Tin, A.* ; Matias-Garcia, P.R. ; Thio, C.H.L.* ; Joehanes, R.* ; Liu, H.* ; Weihs, A.* ; Yu, Z.* ; Hoppmann, A.* ; Grundner-Culemann, F.* ; Min, J.L.* ; Adeyemo, A.A.* ; Agyemang, C.* ; Ärnlöv, J.* ; Aziz, N.A.* ; Baccarelli, A.* ; Bochud, M.* ; Brenner, H.* ; Breteler, M.M.B.* ; Carmeli, C.* ; Chaker, L.* ; Chambers, J.C.* ; Cole, S.A.* ; Coresh, J.* ; Corre, T.* ; Correa, A.* ; Cox, S.R.* ; de Klein, N.* ; Delgado, G.E.* ; Domingo-Relloso, A.* ; Eckardt, K.U.* ; Ekici, A.B.* ; Endlich, K.* ; Evans, K.L.* ; Floyd, J.S.* ; Fornage, M.* ; Franke, L.* ; Fraszczyk, E.* ; Gao, X.* ; Ghanbari, M.* ; Ghasemi, S.* ; Gieger, C. ; Greenland, P.* ; Grove, M.L.* ; Harris, S.E.* ; Hemani, G.* ; Henneman, P.* ; Herder, C.* ; Horvath, S.* ; Hou, L.* ; Hurme, M.A.* ; Hwang, S.J.* ; Jarvelin, M.R.* ; Kardia, S.L.R.* ; Kasela, S.* ; Kleber, M.E.* ; Koenig, W.* ; Kooner, J.S.* ; Kramer, H.* ; Kronenberg, F.* ; Kühnel, B. ; Lehtimäki, T.* ; Lind, L.* ; Liu, D.* ; Liu, Y.* ; Lloyd-Jones, D.M.* ; Lohman, K.* ; Lorkowski, S.* ; Lu, A.T.* ; Marioni, R.E.* ; März, W.* ; McCartney, D.L.* ; Meeks, K.A.C.* ; Milani, L.* ; Mishra, P.P.* ; Nauck, M.* ; Navas-Acien, A.* ; Nowak, C.* ; Peters, A. ; Prokisch, H. ; Psaty, B.M.* ; Raitakari, O.T.* ; Ratliff, S.M.* ; Reiner, A.P.* ; Rosas, S.E.* ; Schöttker, B.* ; Schwartz, J.* ; Sedaghat, S.* ; Smith, J.A.* ; Sotoodehnia, N.* ; Stocker, H.R.* ; Stringhini, S.* ; Sundström, J.* ; Swenson, B.R.* ; Tellez-Plaza, M.* ; van Meurs, J.B.J.* ; van Vliet-Ostaptchouk, J.V.* ; Venema, A.* ; Verweij, N.* ; Walker, R.M.* ; Wielscher, M.* ; Winkelmann, J. ; Wolffenbuttel, B.H.R.* ; Zhao, W.* ; Zheng, Y.* ; Estonian Biobank Research Team* ; Genetics of DNA Methylation Consortium* ; Loh, M.* ; Snieder, H.* ; Levy, D.* ; Waldenberger, M. ; Susztak, K.* ; Köttgen, A.* ; Teumer, A.*

Meta-analyses identify DNA methylation associated with kidney function and damage.

Nat. Commun. 12:7174 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
Impact Factor
Scopus SNIP
Altmetric
14.919
3.055
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Glomerular-filtration-rate; Mendelian Randomization; Disease Gckd; Loci; Albuminuria; Management; Discovery; Haplotype; Elements; Outcomes
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 7174 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Neurogenomics (ING)
POF-Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504091-001
G-504000-010
G-503292-001
G-503200-001
Grants Projekt DEAL
DOI 10.1038/s41467-021-27234-3
WOS ID WOS:000728562700022
Scopus ID 85120946524
PubMed ID 34887417
Erfassungsdatum 2022-01-31
[➜Report correction]