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Retrotransposing a promoter for development.

Nat. Cell Biol. 23, 1221-1223 (2021)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Formerly regarded as 'junk' DNA, transposable elements are now thought to be players in genome evolution. A new study reveals remarkable conservation of a retrotransposon insertion acting as an alternative promoter to drive the expression of a cell cycle regulator isoform in early embryos, potentially controlling the timing of pre-implantation development.
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Publication type Article: Journal article
Document type Editorial
Keywords Mouse; Elements; Enhancer; Line-1; Genes
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1465-7392
e-ISSN 1476-4679
Quellenangaben Volume: 23, Issue: , Pages: 1221-1223 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-506200-001
Grants Deutsche Forschungsgemeinschaft (German Research Foundation)
Scopus ID 85121341363
PubMed ID 34873284
Erfassungsdatum 2021-12-22