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Kraus, U. ; Breitner-Busch, S. ; Schnelle-Kreis, J. ; Cyrys, J. ; Lanki, T.* ; Rückerl, R. ; Schneider, A.E. ; Brüske, I. ; Gu, J.W. ; Devlin, R.* ; Wichmann, H.-E. ; Zimmermann, R. ; Peters, A.

Particle-associated organic compounds and symptoms in myocardial infarction survivors.

Inhal. Toxicol. 23, 431-447 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Context: The aerosol components responsible for the adverse health effects of the exposure to particulate matter (PM) have not been conclusively identified, and there is especially little information on the role of particulate organic compounds (POC). Objective: This study evaluated the role of PM and POC with regard to daily symptoms. Methods: One hundred and fifty-three myocardial infarction survivors from Augsburg, Germany, recorded daily occurrence of different symptoms in winter 2003/2004. Ambient concentrations of PM with a diameter <2.5 μm (PM(2.5)), particle number concentration (PNC), PM(2.5)-bound hopanes, and polycyclic aromatic hydrocarbons (PAH) were quantified. Data were analyzed using generalized estimating equations adjusting for meteorological and other time-variant confounders. Results: The odds for avoidance of physically demanding activities due to heart problems increased immediately associated with most POC measures (e.g. 5% per 1.08 ng/m(3) increase in benzo[a]pyrene, 95%-confidence interval (CI):1-9%) and tended to a delayed decrease. After a 2-day delayed decrease associated with hopanes, the odds for shortness of breath increased consistently after 3 days with almost all POC measures (e.g. 4% per 0.21 ng/m(3) increase in 17α(H), 21β(H)-hopane, CI: 1-8%). The odds for heart palpitations marginally increased immediately in association with PNC (8% per 8146 cm(-3) increase in PNC, CI: 0-16%). Conclusions: The study showed an association between PM, particle-bound POC, and daily symptoms. The organic compounds may be causally related with cardiovascular health or act rather as indicators for traffic- and combustion-related particles.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Air pollution; hopanes; PAH; polycyclic aromatic hydrocarbons; symptoms
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 0895-8378
e-ISSN 1091-7691
Journal Inhalation Toxicology
Quellenangaben Volume: 23, Issue: 7, Pages: 431-447 Article Number: , Supplement: ,
Publisher Informa Healthcare
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Cooperation Group Comprehensive Molecular Analytics (CMA)
POF-Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
Environmental Sciences
PSP Element(s) G-504000-001
G-503900-001
G-504500-001
PubMed ID 21639711
DOI 10.3109/08958378.2011.580471
WOS ID 000291276200006
Scopus ID 79958163211
Erfassungsdatum 2011-06-30
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