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Physiological doses of hydroxytyrosol modulate gene expression in skeletal muscle of exercised rats.
Life 11:1393 (2021)
We tested whether physiological doses of hydroxytyrosol (HT) may alter the mRNA transcription of key metabolic genes in exercised skeletal muscle. Two groups of exercise-trained Wistar rats, HTlow and HTmid, were supplemented with 0.31 and 4.61 mg/kg/d of HT, respectively, for 10 weeks. Another two groups of rats were not supplemented with HT; one remained sedentary and the other one was exercised. After the experimental period, the soleus muscle was removed for qRT-PCR and western blot analysis. The consumption of 4.61 mg/kg/d of HT during exercise increased the mRNA expression of important metabolic proteins. Specifically, 4.61 mg/kg/d of HT may upregulate long-chain fatty acid oxidation, lactate, and glucose oxidation as well as mitochondrial Krebs cycle in trained skeletal muscle. However, a 4.61 mg/kg/d of HT may alter protein translation, as in spite of the increment showed by CD36 and GLUT4 at the mRNA level this was not translated to higher protein content.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Gene Expression ; Glycolysis ; Mitochondria ; Polyphenols; Virgin Olive Oil; Mitochondrial; Mct1; Antioxidant; Population; Increases; Reveals; Heart
ISSN (print) / ISBN
2075-1729
e-ISSN
2075-1729
Journal
Life
Quellenangaben
Volume: 11,
Issue: 12,
Article Number: 1393
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
Grants
CTS-454
3650
3650