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Loeffelholz, C.V.* ; Roth, J.* ; Coldewey, S.M.* ; Birkenfeld, A.L.

The role of physical activity in nonalcoholic and metabolic dysfunction associated fatty liver disease.

Biomedicines 9:1853 (2021)

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	Open Access Gold

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Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and particularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, prediabetes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients' motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Amp Activated Protein Kinase ; Ectopic Lipids ; Insulin Resistance ; Nonexercise Activity Thermogenesis ; Type 2 Diabetes; Life-style Intervention; Impaired Glucose-tolerance; Short-term Exercise; Protein-kinase-c; Insulin-resistance; Hepatocellular-carcinoma; Mitochondrial-function; Diabetes Prevention; Phosphatidic-acid; Fibrosis Stage

ISSN (print) / ISBN 2227-9059

e-ISSN 2227-9059

Journal Biomedicines

Quellenangaben Volume: 9, Issue: 12, Article Number: 1853

Publisher MDPI

Publishing Place Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)

Grants Federal Ministry of Education and Research within the Centre for Innovation Competence Septomics
DFG